bepipred3

Predict linear B-cell epitopes from protein sequences using ESM-2 embeddings.

Updated Aug 27, 2026
One-click install
npx skills add https://github.com/yjcyxky/biominer-skills --skill bepipred3
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: bepipred3
Source: https://github.com/yjcyxky/biominer-skills/tree/main/bepipred3
Command: npx skills add https://github.com/yjcyxky/biominer-skills --skill bepipred3

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

BepiPred-3.0 provides rapid prediction of linear B-cell epitopes from protein sequences using ESM-2 embeddings, enabling researchers to identify immunogenic regions without manual per-sequence analysis.

Core Features & Use Cases

  • GPU-accelerated epitope prediction: Run predictions on protein sequences with per-residue probability scores and interactive HTML visualization.
  • Vaccine design & antigen analysis: Supports rapid screening of candidate sequences for immunogenic regions, aiding design and validation workflows.
  • Use Case: For a set of viral protein sequences, run bepipred3 to obtain per-residue scores and visualizations to prioritize epitopes for experimental testing.

Quick Start

Use the bepipred3 skill to predict epitopes for input sequences using the provided CLI and Docker image ghcr.io/open-prophetdb/bepipred3:arm64-blackwell.

Frequently Asked Questions about bepipred3

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I predict B-cell epitopes from protein sequences for vaccine design?

B-cell epitope prediction is performed using ESM-2 embeddings to generate per-residue probability scores and interactive visualizations from input protein sequences, aiding vaccine design and antigen analysis.

What is linear B-cell epitope prediction and how does ESM-2 work for it?

Linear B-cell epitope prediction identifies immunogenic protein regions using ESM-2 embeddings to generate per-residue probability scores, enabling rapid screening of candidate sequences without manual analysis.

Do I need a GPU and Docker to run ESM-2 epitope predictions?

Yes, this Skill requires the GPU-accelerated Docker image ghcr.io/open-prophetdb/bepipred3:arm64-blackwell to process protein sequences and generate per-residue epitope probability scores and visualizations.

What output formats do I get from B-cell epitope prediction?

B-cell epitope prediction outputs include FASTA and CSV files containing per-residue probability scores, alongside interactive HTML visualizations for analyzing identified immunogenic regions.

Can I use this Skill to screen viral protein sequences for immunogenic regions?

Yes, you can input viral protein sequences to obtain per-residue probability scores and visualizations, enabling rapid screening and prioritization of candidate epitopes for experimental testing.