bio-crispr-screens-library-design
OfficialGuided CRISPR library design for your screens.
Authorstellaromics
Version1.0.0
Installs0
System Documentation
What problem does it solve?
This skill helps researchers design CRISPR sgRNA libraries for genetic screens by providing a structured, tutorial-style guide that covers sgRNA scoring, PAM considerations, off-target filtering, and oligo design for cloning.
Core Features & Use Cases
- Targeted and genome-wide design: select high-quality sgRNAs for knockout, CRISPRi/a, or activation libraries with robust filtering.
- Library construction guidance: assemble guides into library tables and generate cloning-ready oligos with vector-compatible adapters.
- Quality and controls: incorporate non-targeting and essential control guides, and assess off-target risk and design compliance.
Quick Start
Provide a gene list and let the skill design an optimized sgRNA set.
Dependency Matrix
Required Modules
None requiredComponents
Standard package💻 Claude Code Installation
Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.
Please help me install this Skill: Name: bio-crispr-screens-library-design Download link: https://github.com/stellaromics/fast-bioinfo/archive/main.zip#bio-crispr-screens-library-design Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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