Design protein binders for 15-PGDH using BoltzGen on Lyceum.
npx skills add https://github.com/alex-hh/in-silico-pgdh --skill boltzgen-pgdh
Please help me install this Agent Skill. Skill: boltzgen-pgdh Source: https://github.com/alex-hh/in-silico-pgdh/tree/main/.claude/skills/boltzgen-pgdh Command: npx skills add https://github.com/alex-hh/in-silico-pgdh --skill boltzgen-pgdh
This Skill automates the design of protein binders targeting the 15-PGDH enzyme using the BoltzGen tool on the Lyceum platform, streamlining the drug discovery process.
Run BoltzGen for the active site blocker strategy against 15-PGDH using the provided configuration.
High-intent search queries and answers about installing and using this skill.
You can design protein binders targeting 15-PGDH by using BoltzGen on the Lyceum platform. The process automates binder generation for specific strategies like active site blocking, dimer interface disruption, or surface binding.
Supported 15-PGDH binder design strategies include active site blocking, dimer interface disruption, and surface binding. These approaches allow you to target different functional mechanisms of the enzyme for therapeutic intervention.
Yes, Lyceum authentication is required to run BoltzGen for protein binder design. The process orchestrates design jobs on the Lyceum GPU cluster, necessitating valid credentials for automated job submission and result retrieval.
Generating 15-PGDH protein binders requires specific input YAML configurations and target structure files. These inputs define the binding strategy and structural parameters needed to execute the design jobs on the Lyceum platform.
Automated job submission for computational protein design works by sending your YAML configurations and target structures to the Lyceum GPU cluster. It manages the full lifecycle from design generation to result download.
TianyuDuOperate Stanford's Marlowe HPC cluster with Slurm job submission and monitoring.
ANakaAnalyze protein-protein and protein-ligand interfaces in designed complexes via PyMOL.
alex-hhScore 15-PGDH binder designs using the ipSAE metric on Lyceum.
alex-hhSynchronize and rank protein binder designs for the 15-PGDH target.
