bwa-mem2-alignment
CommunityAccelerate genome alignment with BWA-MEM2, achieving 2-3x speedup with identical results.
Authorpradyumnasagar
Version1.0.0
Installs0
System Documentation
What problem does it solve?
This Skill provides a significant speedup in genome alignment using BWA-MEM2, enabling faster processing of genomic data without compromising on accuracy.
Core Features & Use Cases
- Speedup: Achieve 2-3x faster alignment compared to BWA-MEM.
- Accuracy: Maintains identical results to BWA-MEM.
- Use Case: Ideal for production pipelines where alignment time is a bottleneck, such as WGS and WES pipelines.
Quick Start
Align a human genome with BWA-MEM2 by running the following command: bwa-mem2 mem -t 16 -M -K 100000000 -R '@RG... reference/genome.fa reads/R1.fq.gz reads/R2.fq.gz | samtools sort -@ 8 -m 4G -o s1.sorted.bam -
Dependency Matrix
Required Modules
bwa-mem2samtools
Components
scriptsreferences
💻 Claude Code Installation
Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.
Please help me install this Skill: Name: bwa-mem2-alignment Download link: https://github.com/pradyumnasagar/open-research-skills/archive/main.zip#bwa-mem2-alignment Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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