cbioportal-database

Access cancer genomics data via the cBioPortal REST API.

48|6|Updated Mar 9, 2026
One-click install
npx skills add https://github.com/qinyan-ai/qinyan-academic-skills --skill cbioportal-database-qinyan-ai
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: cbioportal-database
Source: https://github.com/qinyan-ai/qinyan-academic-skills/tree/main/skills/07-%E4%B8%B4%E5%BA%8A%E5%8C%BB%E5%AD%A6%E4%B8%8E%E7%B2%BE%E5%87%86%E5%8C%BB%E7%96%97/cbioportal-database
Command: npx skills add https://github.com/qinyan-ai/qinyan-academic-skills --skill cbioportal-database-qinyan-ai

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

Researchers need programmatic access to multi-omics cancer genomics data to perform mutation, CNA, expression, and clinical analyses across many studies without manual scraping or ad-hoc data extraction.

Core Features & Use Cases

  • Provides REST API access to cBioPortal data for mutations, CNAs, mRNA expression, RPPA, methylation, and clinical attributes.
  • Enables gene-centric queries, study-wide summaries, and pan-cancer comparisons to identify associations between genomic alterations and clinical outcomes.
  • Supports reproducible workflows by leveraging defined endpoints and structured responses for downstream analysis.

Quick Start

Use cbioportal-database to fetch study mutations for a gene across TCGA/GENIE studies and export results.

Frequently Asked Questions about cbioportal-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I fetch cancer genomics data from cBioPortal via REST API?

You can fetch cancer genomics data from cBioPortal by using this Skill to query REST API endpoints for study-wide mutations, CNAs, expression, and clinical attributes. It provides structured responses for direct downstream analysis.

Can I perform pan-cancer mutation analysis across TCGA and GENIE studies?

Yes, you can perform pan-cancer mutation analysis across TCGA and GENIE studies. This Skill enables gene-centric queries and study-wide summaries to compare genomic alterations and clinical outcomes across multiple large cancer datasets.

What clinical data attributes can I extract from cBioPortal for survival analysis?

You can extract clinical data attributes from cBioPortal for survival analysis by retrieving sample-level clinical data through defined API endpoints. This supports correlating genomic alterations with clinical outcomes across available studies.

How do I retrieve mRNA expression and methylation profiles for specific genes?

To retrieve mRNA expression and methylation profiles for specific genes, use this Skill to query gene-centric endpoints in cBioPortal. It delivers sample-level retrieval for multi-omics profiling including mRNA, RPPA, and methylation data.

Does this approach support reproducible workflows for cancer genomics data extraction?

Yes, this approach supports reproducible workflows for cancer genomics data extraction. By leveraging defined cBioPortal REST API endpoints and structured data responses, it eliminates manual scraping and ensures consistent data retrieval.

What is the best way to correlate genomic alterations with clinical outcomes in cancer studies?

The best way to correlate genomic alterations with clinical outcomes in cancer studies is through programmatic API access. This Skill retrieves mutation landscapes and clinical attributes from cBioPortal to identify associations across TCGA and GENIE datasets.