cbioportal-database

Query cancer genomics mutations and CNA data by fetching gene alterations through the cBioPortal REST API. It retrieves molecular profiles and sample lists across studies like brca_tcga to enable precise, reproducible gene-centric analyses.

You can correlate mutation data with clinical survival outcomes by retrieving clinical attributes and survival data via the cBioPortal REST API. It supports pan-cancer comparisons across studies like genie_14_1_public to validate biomarkers.

Access clinical attributes and expression data for pan-cancer analyses by using cBioPortal REST endpoints to retrieve study metadata and molecular profiles. This enables genotype-phenotype correlations across multiple cancer studies.

Yes, you need to perform a gene lookup using the /genes/fetch endpoint before retrieving genomic alteration data. This ensures precise targeting when querying mutations, copy-number alterations, and expression profiles across cBioPortal studies.

The cBioPortal API supports querying copy-number alterations alongside mutation profiles through its REST endpoints. It retrieves comprehensive genomic alteration data, integrating CNA and mutation data for targeted gene analyses across studies.

Limitations include dependency on cBioPortal REST API rate limits and study-specific data availability when retrieving study metadata and molecular profiles. Queries require precise gene lookups and study identifiers to return reproducible genomic alteration results.