clinpgx-database

Gene-drug interactions and CPIC guidelines are retrieved programmatically via REST API endpoints that query the ClinPGx database. The Skill provides endpoints for gene, chemical, geneDrugPair, guideline, and allele queries, returning JSON-formatted results with rate limiting (2 requests per second) to support clinical decision support workflows without mandatory authentication.

Yes, the Skill includes dedicated allele endpoints that retrieve variant data, allele functions, and population-specific frequencies. This enables annotation of adverse drug risk and metabolism effects across diverse populations to inform pharmacogenetic treatment selection.

The ClinPGx database implements REST API endpoints returning JSON-formatted responses. Responses include gene-drug pair data, CPIC guideline annotations, allele functional classifications, and drug label information, all structured for integration into clinical workflows.

No mandatory authentication is required for basic use of the pharmacogenomics database. The Skill implements rate limiting (2 requests per second) and optional caching to support robust access. The only dependency is the `requests` library for HTTP communication.

Rate limiting enforces 2 requests per second to prevent service overload. Optional caching can mitigate repeated queries. The REST API structure supports typical clinical decision support volumes, but high-throughput batch operations should account for rate-limit windows and use caching strategically.

ClinPGx provides CPIC guideline-aligned data, allele functional annotations, population frequencies, and drug label integration in a single programmatic interface. This combines curated clinical guidance with variant-level detail, distinguishing it from reference-only or genotype-only alternatives in precision medicine workflows.