decoupler-tf-activity
CommunityInfer TF activities from differential expression.
Authortony-zhelonkin
Version1.0.0
Installs0
System Documentation
What problem does it solve?
Infers transcription factor activities from differential expression results using a univariate linear model (ULM) with CollecTRI regulatory weights, enabling quantification of TF activity changes from DE outputs.
Core Features & Use Cases
- Infers per-TF activity scores and p-values from DE results using CollecTRI networks via OmnipathR.
- Supports multi-contrast analyses and construction of master TF activity tables for downstream integration.
- Provides guidance and options to use DoRothEA as an alternative regulon source and to handle species mapping.
Quick Start
Load your DE t-statistics, fetch the CollecTRI network, and run the ULM workflow to generate TF activity scores and p-values.
Dependency Matrix
Required Modules
None requiredComponents
Standard package💻 Claude Code Installation
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Please help me install this Skill: Name: decoupler-tf-activity Download link: https://github.com/tony-zhelonkin/SciAgent-toolkit/archive/main.zip#decoupler-tf-activity Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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