Analyze DepMap Chronos scores to identify cancer cell line dependencies and drug targets.
npx skills add https://github.com/crazymsn/academic-skills --skill depmap-crazymsn
Please help me install this Agent Skill. Skill: depmap Source: https://github.com/crazymsn/academic-skills/tree/main/academic-skills/depmap Command: npx skills add https://github.com/crazymsn/academic-skills --skill depmap-crazymsn
DepMap provides comprehensive gene dependency scores and cell line annotations to identify cancer-specific vulnerabilities and validate targets, enabling researchers to map essential genes and potential synthetic lethal interactions.
Query Chronos scores for a target gene across the DepMap panel and examine which cell lines show strong dependency, then assess selectivity by cancer type.
High-intent search queries and answers about installing and using this skill.
To identify synthetic lethality partners, you analyze Chronos gene effect scores across DepMap cell lines and correlate gene dependencies with specific biomarkers. This process filters and merges dependency data to reveal selective vulnerabilities and potential drug targets.
Finding selective gene dependencies involves querying Chronos gene effect scores across the DepMap panel and merging them with sample metadata. By grouping cell lines by lineage or primary disease, you can summarize and assess which tissue types show strong target vulnerability.
Yes, you can perform biomarker-assisted analysis by merging Chronos gene effect data with cell line mutation and sample info. This approach reveals biomarker-driven targets and co-essentiality patterns to prioritize potential therapeutic vulnerabilities.
Yes, you need basic Python data processing to filter, merge, and summarize DepMap data. Access to Chronos scores and sample info files is required to manipulate the datasets and extract cancer cell line dependencies effectively.
Co-essentiality screening works by comparing gene dependency correlations across hundreds of cancer cell lines using Chronos scores. This analysis identifies genes with similar dependency patterns, validating targets and revealing potential synthetic lethal interactions.
fuzzy-dynamicsAnalyze Chronos gene dependency scores across DepMap cell lines.
qinyan-aiQuery DepMap data for gene dependencies and drug sensitivities in cancer cell lines.
jackspaceQuery the Ensembl REST API for gene, sequence, and variant data.
felixboehmQuery DepMap for gene dependency scores and drug sensitivity data.
