Query DepMap for gene dependency scores and drug sensitivity data.
npx skills add https://github.com/felixboehm/biochem-allergy --skill depmap-felixboehm
Please help me install this Agent Skill. Skill: depmap Source: https://github.com/felixboehm/biochem-allergy/tree/main/.claude/skills/depmap Command: npx skills add https://github.com/felixboehm/biochem-allergy --skill depmap-felixboehm
This Skill helps researchers and drug developers identify genetic vulnerabilities in cancer cell lines, accelerating the discovery of new cancer therapies.
Use the depmap skill to find genes that lung cancer cell lines are selectively dependent on.
High-intent search queries and answers about installing and using this skill.
To find gene dependency scores, query the Cancer Dependency Map for CRISPR Chronos gene effect profiles across hundreds of cancer cell lines. This reveals specific genetic vulnerabilities and gene knockouts essential for survival in targeted cancer types.
Synthetic lethality occurs when simultaneous loss of two genes is lethal to a cancer cell, while losing either alone is tolerated. Identify these targeted therapy opportunities by analyzing gene dependency profiles and drug sensitivity data in the DepMap dataset.
Yes, you can use PRISM assay data to discover predictive biomarkers by querying drug sensitivity data alongside genomic features. This helps identify specific cancer vulnerabilities and genomic markers predicting treatment response across various cancer cell lines.
Validate oncology drug targets by querying dependency mapping data for gene effect profiles and drug sensitivity scores across cancer cell lines. This confirms whether knocking out a specific target gene significantly reduces survival in your cancer type of interest.
Yes, querying the Cancer Dependency Map works for identifying dependencies in specific cancer types like lung cancer. Filter cell lines by lineage to find genes where knockout leads to a significant dependency score in your targeted cancer type.
Lord1EgyptPerform end-to-end single-cell RNA-seq analysis with AnnData.
yf8578Query DepMap for gene dependency scores and drug sensitivity across cancer cell lines.
Zeyuyang-0420Query gene dependency scores and drug sensitivity data across cancer cell lines.
mims-harvardIdentify drug repurposing candidates across disease targets, drugs, and safety data.
