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depmap

Query gene dependency scores and drug sensitivity data across cancer cell lines.

Updated May 8, 2026
Search Tags:#bioinformatics#cancer research#gene dependency#drug sensitivity#DepMap
One-click install
npx skills add https://github.com/Zeyuyang-0420/bio-ai-research-skills --skill depmap-zeyuyang-0420
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: depmap
Source: https://github.com/Zeyuyang-0420/bio-ai-research-skills/tree/main/categories/bioinformatics-genomics/depmap
Command: npx skills add https://github.com/Zeyuyang-0420/bio-ai-research-skills --skill depmap-zeyuyang-0420

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes scripts (resource) and references (resource) components.

What problem does it solve?

This Skill provides access to the Cancer Dependency Map (DepMap) data, allowing users to identify cancer-specific vulnerabilities, synthetic lethal interactions, and validate oncology drug targets.

Core Features & Use Cases

  • Gene Dependency Scores: Query gene dependency scores across cancer cell lines using CRISPR Chronos, RNAi DEMETER2, and gene effect profiles.
  • Drug Sensitivity Data: Access drug sensitivity data for cancer cell lines.
  • Use Case: A researcher could use this Skill to identify genes that are essential for survival in cancer cell lines with a specific mutation, such as KRAS-mutant lung cancer cells.

Quick Start

Use the depmap skill to get gene dependency scores for the gene 'KRAS' across all cell lines.

Frequently Asked Questions about depmap

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I query gene dependency scores for specific cancer cell lines?▼

Query gene dependency scores by targeting specific genes like 'KRAS' across cancer cell lines using CRISPR Chronos, RNAi DEMETER2, and gene effect profiles to identify cancer-specific vulnerabilities.

What is the difference between CRISPR Chronos and RNAi DEMETER2 dependency data?▼

CRISPR Chronos and RNAi DEMETER2 are distinct gene effect profiling methods provided to query gene dependency scores, allowing you to validate oncology drug targets and compare gene essentiality across cancer cell lines.

Can I access drug sensitivity data for cancer cell lines to validate drug targets?▼

Yes, you can access drug sensitivity data for cancer cell lines to identify synthetic lethal interactions and validate oncology drug targets alongside gene dependency scores.

How do I identify genes essential for survival in KRAS-mutant lung cancer cells?▼

Identify genes essential for survival in KRAS-mutant lung cancer cells by querying gene dependency scores across all available cancer cell lines to pinpoint specific genetic vulnerabilities.

Does this data support identifying synthetic lethal interactions in cancer research?▼

Yes, the data supports identifying synthetic lethal interactions in cancer research by providing gene dependency scores and drug sensitivity data to pinpoint cancer-specific vulnerabilities for target validation.

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