Query the Cancer Dependency Map for gene dependency scores and drug sensitivity data.
npx skills add https://github.com/tassiovale/claude-code-kit --skill depmap-tassiovale
Please help me install this Agent Skill. Skill: depmap Source: https://github.com/tassiovale/claude-code-kit/tree/main/skills/depmap Command: npx skills add https://github.com/tassiovale/claude-code-kit --skill depmap-tassiovale
This Skill simplifies querying the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores, drug sensitivity data, and gene effect profiles, aiding in identifying cancer-specific vulnerabilities and validating oncology drug targets.
Query the gene dependency scores for the gene 'KRAS' in the dataset 'Chronos_Combined'.
High-intent search queries and answers about installing and using this skill.
To query gene dependency scores using CRISPR Chronos data, you can access the Cancer Dependency Map (DepMap) to retrieve gene effect profiles and dependency scores for specific genes like KRAS across various cancer cell lines.
You can find drug sensitivity data for biomarker discovery by querying the DepMap portal, which provides compound sensitivity analysis and comprehensive cell line annotations including cancer types and tissue lineages.
Yes, you can perform synthetic lethality screening using DepMap gene effect profiles. The process requires Python libraries including requests, pandas, numpy, and scipy to analyze the dependency scores.
The best way to validate oncology drug targets using cell line dependency scores is by analyzing CRISPR Chronos and RNAi DEMETER2 datasets in DepMap to identify cancer-specific vulnerabilities.
Querying the DepMap API requires Python dependencies including requests, pandas, numpy, and scipy to perform target validation, biomarker discovery, and compound sensitivity analysis.
Limitations between RNAi DEMETER2 and CRISPR Chronos for target validation involve differing gene effect profiles. Both datasets are accessible via the DepMap API to cross-reference dependency scores and account for screening artifacts.
andikarachmanAudit Python version and installed DS/ML libraries for environment readiness.
dailycafiMap metabolites to KEGG, Reactome, and SMPDB pathways with enrichment and topology analysis.
biomaps-infraQuery DepMap for cancer cell line gene dependency and drug sensitivity data.
Yezez9Queries the DepMap database for gene dependency scores across cancer cell lines.
