ensembl-database

Access Ensembl REST API for gene lookups, sequence retrieval, and VEP variant analysis.

Updated Aug 23, 2026
One-click install
npx skills add https://github.com/Zehong-Wang/Kosmos --skill ensembl-database-zehong-wang
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: ensembl-database
Source: https://github.com/Zehong-Wang/Kosmos/tree/main/kosmos-claude-scientific-skills/scientific-skills/ensembl-database
Command: npx skills add https://github.com/Zehong-Wang/Kosmos --skill ensembl-database-zehong-wang

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires requests, ensembl_rest, and includes scripts (resource) and references (resource) components.

What problem does it solve?

This Skill provides programmatic access to the Ensembl genome database, enabling researchers to retrieve comprehensive genomic data for over 250 species without manual web browsing.

Core Features & Use Cases

  • Gene Information: Look up genes by symbol or ID, retrieve sequences, and find cross-references.
  • Variant Analysis: Analyze genetic variants, predict their functional consequences using VEP, and access population data.
  • Comparative Genomics: Identify orthologs and paralogs across species to understand evolutionary relationships.
  • Use Case: A biologist needs to find all known human genes associated with a specific chromosomal region and retrieve their protein sequences for further analysis.

Quick Start

Use the ensembl-database skill to find all genes in the human genomic region 7:140424943-140624564.

Frequently Asked Questions about ensembl-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I retrieve genomic sequences from the Ensembl REST API?

Retrieve genomic sequences from the Ensembl REST API by querying gene symbols or IDs. The skill facilitates sequence retrieval and cross-references for over 250 species, returning raw sequence data for bioinformatics pipelines without manual web browsing.

Can I analyze genetic variants and predict functional consequences using VEP?

Yes, you can analyze genetic variants and predict functional consequences using VEP. The skill accesses the Ensembl REST API to perform variant analysis, evaluate functional impacts, and retrieve population data programmatically for genomic research.

How do I find orthologs and paralogs for comparative genomics across species?

Find orthologs and paralogs for comparative genomics by querying the Ensembl database through this skill. It identifies evolutionary relationships across 250+ species to support comparative genomics research and programmatic integration into pipelines.

Does the Ensembl REST API support coordinate mapping between genome assemblies?

Yes, the Ensembl REST API supports coordinate mapping between genome assemblies. This skill facilitates coordinate mapping alongside gene lookups and variant analysis, enabling programmatic integration into bioinformatics pipelines for genomic research.

What's the best way to look up genes in a specific chromosomal region?

Look up genes in specific chromosomal regions by querying the Ensembl REST API. The skill facilitates gene lookups using genomic coordinates, such as human region 7:140424943-140624564, to retrieve associated genes and protein sequences.

Do I need the ensembl_rest library to use this skill for genomic research?

Yes, you need the ensembl_rest library and requests library installed. These dependencies allow the skill to access the Ensembl REST API for genomic research, sequence retrieval, and variant analysis across multiple species.