esm

Design, analyze, and embed proteins with ESM3 and ESM C.

1|Updated Mar 4, 2026
One-click install
npx skills add https://github.com/Hung-3008/agusta --skill esm-hung-3008
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: esm
Source: https://github.com/Hung-3008/agusta/tree/main/.agents/skills/esm
Command: npx skills add https://github.com/Hung-3008/agusta --skill esm-hung-3008

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

Researchers need a unified workflow for protein design, structure prediction, and embedding generation using ESM models.

Core Features & Use Cases

  • Multimodal protein design across sequence, structure, and function with ESM3.
  • Efficient protein embeddings and representations via ESM C.
  • Inverse folding, structure-aware design, and Forge-based scalable inference.
  • Use case example: design a novel protein, predict structure, and generate embeddings for ML tasks.

Quick Start

Load a model, design a sequence, and generate both structure predictions and embeddings in a single step.

Frequently Asked Questions about esm

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I generate protein embeddings and predict structures using ESM?

Generate protein embeddings and predict structures using ESM by loading ESM3 or ESM C models to process sequences and extract structural representations in a single workflow. The Skill supports designing novel proteins and outputting embeddings for ML tasks.

Can I run ESM inverse folding and protein design locally or do I need cloud compute?

You can run ESM inverse folding and protein design locally using Python with PyTorch and the esm package, or utilize Forge-based cloud inference for scalable execution across sequences, structures, and functions.

What is the best way to design a novel protein across sequence, structure, and function?

The best way to design a novel protein across sequence, structure, and function is using ESM3 for multimodal design, enabling researchers to simultaneously generate sequences, predict structures, and define functional constraints.

Do I need PyTorch and the esm package to use ESM for protein analysis?

Yes, you need Python with PyTorch and the esm package installed to run ESM models locally for protein analysis. The Skill relies on these dependencies to execute structure prediction and embedding generation.

How does ESM C differ from ESM3 for generating protein representations?

ESM C differs from ESM3 by focusing on efficient protein embeddings and representations, whereas ESM3 provides multimodal capabilities across sequence, structure, and function for comprehensive protein design tasks.

Can ESM handle scalable inference for large protein datasets on Forge?

Yes, ESM supports scalable inference for large protein datasets on the Forge cloud API, allowing researchers to process extensive sequences, structures, and functions without local hardware limitations.