One-click install
npx skills add https://github.com/rubensliv/k-dense-ai --skill esm-rubensliv
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: esm
Source: https://github.com/rubensliv/k-dense-ai/tree/main/scientific-skills/esm
Command: npx skills add https://github.com/rubensliv/k-dense-ai --skill esm-rubensliv

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

Protein researchers need integrated access to modern protein language models to design, embed, and evaluate proteins without managing multiple toolchains. This skill consolidates ESM3 multimodal design capabilities with ESM C embeddings, enabling end-to-end prototyping from sequence design to embedding-based analysis using either local models or Forge API.

Core Features & Use Cases

  • Multimodal design: generate sequences, structures, and function annotations across sequence, structure, and function tracks.
  • Embeddings & analysis: compute high-quality protein embeddings for similarity, clustering, and downstream ML tasks.
  • Flexible deployment: work locally or via Forge for scalable inference and batch processing.

Quick Start

Load an ESM3 model (local or Forge), create an ESMProtein with a partial sequence, and run a simple generation to complete the protein.

Frequently Asked Questions about esm

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I compute protein embeddings for sequence similarity analysis?

Compute protein embeddings for sequence similarity by loading an ESM C model and running it on your sequences to generate high-quality vectors for clustering and downstream ML tasks.

Can I design novel proteins with both sequence and structure constraints?

Design novel proteins with sequence and structure constraints by using ESM3 multimodal generation to create coordinated outputs across sequence, structure, and function annotation tracks.

How do I set up ESM3 for local inference versus Forge API batch processing?

Set up ESM3 for local inference or Forge API batch processing by installing the required esm package, then configuring the model load call to target either your local environment or the Forge endpoint.

What is multimodal protein generation with ESM3?

Multimodal protein generation with ESM3 is the process of creating proteins by simultaneously generating coordinated outputs across sequence, structure, and function annotation tracks from partial inputs.

Does ESM3 support partial sequence inputs for protein completion?

ESM3 supports partial sequence inputs for protein completion by allowing you to create an ESMProtein object with incomplete sequences and running a generation step to fill the missing residues.

What inputs do I need to provide for ESM3 embedding and analysis workflows?

Provide inputs including protein sequences, coordinates, and function annotations to run ESM3 embedding and analysis workflows, allowing the model to process multimodal data for generation and evaluation.