foundation-model-analysis

Coordinate foundation-model workflows for single-cell embedding, annotation, integration, and perturbation prediction.

32|5|Updated Mar 12, 2026
One-click install
npx skills add https://github.com/omicverse/omicclaw --skill foundation-model-analysis-omicverse
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: foundation-model-analysis
Source: https://github.com/omicverse/omicclaw/tree/main/src/omicverse_skills/skills/fm-foundation-models
Command: npx skills add https://github.com/omicverse/omicclaw --skill foundation-model-analysis-omicverse

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

This skill coordinates foundation-model workflows to analyze single-cell data, enabling embedding, annotation, integration, and perturbation predictions through a unified API.

Core Features & Use Cases

  • Unified 6-step FM analysis pipeline: discover models, profile data, select the best model, validate compatibility, execute embeddings or annotations, and interpret results.
  • Supports 22 foundation-models (e.g., scGPT, Geneformer, UCE, CellPLM) and multiple tasks (embed, annotate, integrate, perturb, spatial, drug_response).
  • Enables cross-model comparisons, provenance tracking, and checkpoint management for reproducible analyses.
  • Practical use cases include embedding PBMC data, cross-species comparisons, and large-scale perturbation predictions with cell-type annotations.

Quick Start

Run a complete foundation-model workflow on a single-cell dataset to generate embeddings and annotate cell types.

Frequently Asked Questions about foundation-model-analysis

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I use foundation models for single-cell embedding and annotation?

Single-cell perturbation prediction uses foundation models to forecast cellular responses. This skill profiles data, selects a compatible model, and executes predictions for large-scale perturbation scenarios across diverse datasets.

What's the best way to compare foundation models for single-cell integration?

Comparing foundation models for single-cell integration requires profiling data and checking compatibility across 22 supported models like scGPT and UCE. This skill enforces a 6-step pipeline with cross-model comparisons and provenance tracking for reproducible results.

Does this single-cell foundation model workflow support cross-species datasets?

Cross-species datasets are supported for single-cell foundation model workflows. The pipeline applies embeddings, annotations, and integration tasks to diverse datasets including human and model species through a unified API.

How do I manage checkpoints when running foundation models on single-cell data?

Checkpoint management for foundation models on single-cell data is handled automatically with per-model tracking. The workflow enforces provenance tracking and device selection to ensure reproducible embeddings and annotations.

Can I predict drug response using single-cell foundation models?

Drug response prediction is supported as a task within single-cell foundation model workflows. The pipeline coordinates model selection and execution for drug_response tasks alongside embedding, annotation, integration, and perturbation predictions.

Why do I need a compatibility check before running single-cell embeddings?

A compatibility check before running single-cell embeddings ensures the selected foundation model aligns with your dataset profile. This validation step prevents execution failures and guarantees reproducible results across different models.