generate-research-questions

Generate research questions by processing profile.json and variable_types.json files into a ranked candidate set. The output is a research_questions.json artifact containing primary PICO/PECO questions, secondary questions, and variable role mappings for study design.

The PICO framework structures research questions by defining Population, Intervention, Comparison, and Outcome variables. This skill automatically assigns dataset variables to these roles to generate primary PICO/PECO questions suitable for epidemiology study design.

Yes, you can assess study feasibility by running profiled dataset outputs through rigorous feasibility checks. The process evaluates variable types and data profiles to determine if sufficient data exists to support proposed research questions and study design.

Assign variable roles by mapping dataset variables into outcomes, exposures, covariates, and stratifications based on profile.json and variable_types.json. The skill automatically documents assumptions and outputs these mappings to support robust biostatistics analysis.

Transition from data profiling to study design by converting profile.json and variable_types.json into ranked research questions. This produces a validated research_questions.json artifact that guides downstream literature review and analysis in a reproducible workflow.