gtex-database

To query tissue-specific gene expression and regulatory variants, you can retrieve median TPM by tissue and map cis-eQTL or cis-sQTL associations across 54 tissues using GTEx API v2 endpoints.

Finding cis-eQTL and cis-sQTL associations requires querying regulatory signals by gene or variant across tissues. This maps genetic variants to expression changes, enabling tissue-specific interpretation of genetic associations.

Yes, you can retrieve median gene expression TPM values for specific tissues. The skill queries GTEx API v2 to fetch expression data across 54 distinct tissue types for your target genes.

Yes, GTEx API v2 supports pagination. The skill enforces API usage patterns and handles pagination automatically to efficiently retrieve large datasets of tissue expression and regulatory variants.

You need to map cis-eQTLs and sQTLs when interpreting genetic associations and prioritizing tissues. This links regulatory signals to expression changes, enabling end-to-end workflows for tissue-specific variant interpretation.

Limitations include handling pagination for large queries and enforcing specific API usage patterns. The skill focuses on cis-eQTLs, cis-sQTLs, and median TPM across 54 tissues using GTEx API v2 endpoints.