gtex-database

Query the GTEx API for tissue-specific gene expression and eQTL data by specifying gene identifiers and tissueSiteDetailId parameters. Use endpoints like medianGeneExpression and association/singleTissueEqtl with dataset versioning like gtex_v10 to retrieve expression and regulatory variant associations across 54 tissues.

Yes, you can retrieve sQTL associations alongside eQTLs for multi-tissue regulatory variant analysis. The Skill queries GTEx association endpoints to link genetic variants to both expression and splicing changes across tissue contexts, supporting cross-tissue regulatory analyses.

Interpreting GWAS loci using tissue-specific expression and QTL data involves querying GTEx for median tissue expression and significant eQTLs/sQTLs. This approach prioritizes relevant tissues and maps regulatory variants to gene regulation across tissues for GWAS interpretation.

Yes, this approach supports dataset versioning for GTEx API queries. It requires specifying dataset versions like gtex_v10 to ensure accurate retrieval of expression and regulatory variant association data across tissue contexts.

Handle pagination when retrieving significant eQTLs from the GTEx API by implementing proper pagination handling in your queries. This ensures complete retrieval of association data from endpoints like association/singleTissueEqtl across all relevant tissues.

Specify tissueSiteDetailId parameters for GTEx tissue expression queries when targeting specific tissues across the 54 available options. These parameters are required by endpoints like medianGeneExpression to retrieve tissue-specific gene expression data accurately.