gwas-database

To retrieve SNP-trait associations and p-values from the GWAS Catalog, use variant-centered queries with a specific rsID to fetch matching effect sizes, study metadata, and available summary statistics.

Yes, you can search GWAS summary statistics by trait or gene using trait-centered and gene-centered queries, which return associated variants, p-values, and relevant study metadata across multiple cohorts.

The best way to query pleiotropic effects of a variant across phenotypes is using variant-centered lookups by rsID to fetch all associated traits, effect sizes, and p-values from the GWAS Catalog.

Yes, the GWAS Catalog API supports REST API navigation with HAL, pagination for large result sets, and cross-references to external resources like Ensembl and dbSNP for variant details.

You can filter GWAS association analysis results by significance by applying p-value thresholds to the retrieved variant associations, allowing you to isolate statistically significant SNP-trait findings.

Yes, the system guides robust, rate-limited data access to the GWAS Catalog REST API, ensuring stable queries for genetic epidemiology data without exceeding external server request thresholds.