gwas-database

To query SNP-trait associations by rsID, search the GWAS Catalog REST API using the variant endpoint, which returns genome-wide significant p-values, effect sizes, and links to summary statistics for the specified rsID.

The best way to retrieve summary statistics programmatically is querying the GWAS Catalog REST API endpoints, which provide HAL-formatted JSON responses with direct links to downloadable summary statistics via FTP for downstream pipelines.

Yes, you can search the GWAS Catalog by EFO trait terms, genes, variants, and publications to retrieve matching SNP-trait associations, study metadata, and summary statistics across multiple published GWAS.

Pagination in the GWAS Catalog REST API works by returning HAL-formatted JSON responses with navigation links, allowing you to systematically retrieve large sets of variant data and associations across multiple pages.

Querying GWAS studies provides study-level metadata including p-values, effect sizes, variant associations, and links to summary statistics, enabling interpretation and meta-analysis of published genome-wide association results.

Limitations include handling pagination for large queries and parsing HAL-formatted JSON responses, as the REST API provides structured data links rather than directly pre-processed association tables for analysis.