gwas-database

To find SNP-trait associations for a specific variant like rs7903146, query the NHGRI-EBI GWAS Catalog via REST API using the variant ID to retrieve matching traits, p-values, and effect sizes.

The best way to retrieve GWAS summary statistics for a specific trait or disease is to query the GWAS Catalog API by trait name, which returns detailed study metadata and downloadable summary statistics for genome-wide association studies.

Yes, you can search for genetic variants linked to a particular gene or chromosomal region by querying the GWAS Catalog API with gene names or genomic coordinates to identify associated SNPs and their trait associations.

Yes, querying the GWAS Catalog returns p-values and effect sizes for SNP associations, providing the necessary summary statistics to facilitate genetic epidemiology research and polygenic risk score development.

You need to access the NHGRI-EBI GWAS Catalog programmatically for bioinformatics research when developing polygenic risk scores or conducting genetic epidemiology studies that require bulk retrieval of SNP-trait associations and summary statistics.

A limitation of using the GWAS Catalog for genetic epidemiology research is that retrieval depends entirely on the catalog's existing study metadata and published summary statistics, which may not cover unpublished or rare variant associations.