Calculate polygenic risk scores from 23andMe or AncestryDNA genotype files.
npx skills add https://github.com/ClawBio/ClawBio --skill gwas-prs
Please help me install this Agent Skill. Skill: gwas-prs Source: https://github.com/ClawBio/ClawBio/tree/main/skills/gwas-prs Command: npx skills add https://github.com/ClawBio/ClawBio --skill gwas-prs
This skill automates the calculation and interpretation of polygenic risk scores (PRS) from direct-to-consumer genotype files, removing manual matching, weighting, and statistical conversion steps so users can quickly obtain trait-level risk estimates with provenance and reproducibility.
Calculate my Type 2 diabetes PRS from this 23andMe file and save a Markdown report, CSV scores, and optional figures to the specified output directory.
High-intent search queries and answers about installing and using this skill.
You can calculate polygenic risk scores from 23andMe data by matching your genotypes to PGS Catalog harmonised scoring files and computing dosage-weighted PRS. The skill parses 23andMe formats and estimates trait percentiles against reference distributions.
Yes, you can use AncestryDNA genotype files to compute polygenic risk scores. The skill parses AncestryDNA formats, matches rsIDs to PGS Catalog scoring files, and calculates dosage-weighted scores to estimate trait-level risk percentiles.
A polygenic risk score aggregates genetic effects across variants to estimate trait-level risk. Percentile estimation maps your dosage-weighted score against curated reference mean/SD or allele-frequency-derived distributions to annotate your risk category.
You generate a reproducible PRS report by emitting a structured directory containing a Markdown narrative, CSV score table, optional figures, commands.sh, and environment.yml. The skill also includes checksums to ensure reproducible review.
No, computing PRS from DTC genetic data does not require uploading your file to a server. The skill always keeps genotype data local, performs offline scoring using curated files, and respects API rate limits only when searching the PGS Catalog.
If your genotype file has low coverage or an ancestry mismatch, the skill annotates risk categories and issues warnings. It estimates percentiles using curated reference distributions or allele-frequency-based variance to flag potential accuracy limitations.
jakechen1Analyze consumer DNA data locally and export JSON reports.
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Yezez9Query the NHGRI-EBI GWAS Catalog for SNP-trait associations and summary statistics.
