hypothesis-generation

Generates falsifiable, scored research hypotheses from gap analysis and association outputs.

6|1|Updated May 11, 2026
One-click install
npx skills add https://github.com/yakeworld/Synthos --skill hypothesis-generation-yakeworld
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: hypothesis-generation
Source: https://github.com/yakeworld/Synthos/tree/main/skills/core/hypothesis-generation
Command: npx skills add https://github.com/yakeworld/Synthos --skill hypothesis-generation-yakeworld

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve? Turning identified research gaps and literature contradictions into rigorous, testable hypotheses is slow and inconsistent. This Skill converts gap analysis output into structured, falsifiable hypotheses with quantitative rejection criteria, evidence matrices, and multi-dimensional scoring. ## Core Features & Use Cases - Falsifiable Hypothesis Construction: Every hypothesis includes a statement, rationale, falsifiability test with quantitative rejection criteria, supporting and conflicting evidence, and a five-dimension composite score (novelty, plausibility, testability, clinical impact, feasibility). - Advanced Hypothesis Patterns: Built-in patterns for integration/framework hypotheses (Pattern #4), discriminative experiment design via phase-to-parameter mapping (Pattern #5), and co-primary recommendation strategies (Pattern #6). - Golden-Set Validation: Ships with five test cases (contradiction-driven, method gap, cross-domain analogy, empty input, multi-source) with semantic-equivalence expected outputs and a 0.70 pass threshold. - Use Case: A biomedical researcher finishing a gap analysis on PINN-based physiological modeling feeds the gaps in and receives ranked hypotheses with experiment designs, sample size estimates, and clinical translation paths. ## Quick Start Generate falsifiable, scored research hypotheses from my gap analysis output listing the identified research gaps and literature contradictions.

Frequently Asked Questions about hypothesis-generation

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I generate testable research hypotheses from a gap analysis?

Provide the research gap description, domain knowledge summary, and optional constraints as input. The skill produces structured hypotheses, each with a falsifiability test, quantitative rejection criteria, evidence matrix, and composite priority score.

What makes a hypothesis falsifiable in research?

A falsifiable hypothesis states explicit quantitative conditions under which it would be rejected, such as RMSE thresholds, AUC minimums, or p-value criteria. Hypotheses without rejection criteria are discarded immediately by this skill.

How are generated hypotheses scored and ranked?

Each hypothesis is scored on five weighted dimensions: novelty (0.20), plausibility (0.20), testability (0.20), clinical impact (0.25), and feasibility (0.15). Composite scores map to priority tiers from HIGHEST (>=0.80) to LOW (<0.50).

What input format does hypothesis generation require?

It requires a research_gap string and domain_knowledge string, with optional constraints and prior_hypotheses lists. Empty associations and research_gaps inputs return a MISSING_INPUT error rather than proceeding.

When should I use the co-primary hypothesis strategy?

Use it when two hypotheses have composite scores within 0.05 of each other but complementary strengths, such as one leading in clinical impact and another in novelty. The skill then recommends phased validation of both.