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interpro-database

Query the InterPro REST API for protein domain architecture and family classifications.

298|27|Updated Feb 18, 2026
Search Tags:#bioinformatics#family#domain#proteomics#protein#interpro
One-click install
npx skills add https://github.com/jaechang-hits/SciAgent-Skills --skill interpro-database
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: interpro-database
Source: https://github.com/jaechang-hits/SciAgent-Skills/tree/main/skills/proteomics-protein-engineering/interpro-database
Command: npx skills add https://github.com/jaechang-hits/SciAgent-Skills --skill interpro-database

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires requests, pandas, matplotlib, and includes scripts (resource) and references (resource) components.

What problem does it solve?

This Skill helps researchers understand the functional and evolutionary relationships of proteins by querying the InterPro database for domain architecture, family classification, and related information.

Core Features & Use Cases

  • Domain Architecture: Identify all InterPro entries (domains, families, sites) present in a given protein.
  • Family Membership: Find proteins belonging to a specific InterPro family or domain.
  • Taxonomic Distribution: Analyze the occurrence of a domain/family across different species.
  • Structure Linking: Discover PDB structures associated with InterPro entries.
  • Use Case: Given a UniProt accession, quickly list all the protein domains and families it contains to understand its functional potential.

Quick Start

Query the InterPro API for the domain architecture of the protein with UniProt accession P04637.

Frequently Asked Questions about interpro-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I find all protein domains and families in a UniProt accession?▼

To find protein domains, query the InterPro REST API with a UniProt accession to retrieve its complete domain architecture and family classifications. This reveals all functional entries present in the specific protein.

What is the taxonomic distribution of an InterPro protein family?▼

The taxonomic distribution of an InterPro family maps the occurrence of a specific domain across different species. Querying the InterPro API analyzes this distribution to show evolutionary relationships.

Can I retrieve PDB structures associated with InterPro entries?▼

Yes, you can retrieve PDB structures linked to InterPro entries. The API provides structure linking capabilities to discover associated protein data for specific domain classifications.

Does InterPro integrate with member databases like Pfam and SMART?▼

InterPro integrates with multiple member databases including Pfam, PANTHER, PIRSF, PRINTS, PROSITE, SMART, CDD, and NCBIfam. This integration provides comprehensive protein family classifications.

How do I list all proteins belonging to a specific InterPro family?▼

To list proteins in an InterPro family, search the database by family name or accession. This family membership query returns all proteins classified under that specific domain.

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