interpro-database

Query the InterPro REST API for protein family, domain, and functional site annotations.

Updated Mar 15, 2026

Search Tags:#bioinformatics #domain #annotation #protein #interpro #function prediction

Ready to run

npx skills add https://github.com/sagunkayastha/claude_skills_collection --skill interpro-database-sagunkayastha

💬 Prompt for ChatGPT / Claude Chat▼

Please help me install this Agent Skill.
Skill: interpro-database
Source: https://github.com/sagunkayastha/claude_skills_collection/tree/main/scientific-databases/interpro-database
Command: npx skills add https://github.com/sagunkayastha/claude_skills_collection --skill interpro-database-sagunkayastha

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires requests, and includes scripts (resource) and references (resource) components.

What problem does it solve?

This Skill helps researchers understand protein function, structure, and evolutionary relationships by querying the comprehensive InterPro database.

Core Features & Use Cases

Protein Function Prediction: Determine the likely functions of unknown proteins.
Domain Architecture Analysis: Identify and map protein domains and their order.
Protein Family Classification: Classify proteins into known families and superfamilies.
GO Term Mapping: Associate proteins with Gene Ontology terms for functional annotation.
Use Case: Given a UniProt ID for a newly discovered protein, use this Skill to retrieve all its known domains, families, and associated Gene Ontology terms to infer its biological role.

Quick Start

Use the interpro-database skill to get all InterPro entries for the protein with UniProt ID P04637.

Frequently Asked Questions about interpro-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema

How do I retrieve protein domain annotations and family classifications using a UniProt ID?▼

To retrieve protein domain annotations, you query the InterPro REST API with a UniProt ID. This maps domain architecture, classifies protein families, and retrieves functional site data by integrating multiple member databases like Pfam and PANTHER.

What is the best way to predict protein function for unknown sequences?▼

Protein function prediction is achieved by querying the InterPro database to map Gene Ontology terms and identify functional sites. This associates unknown proteins with known families and domains to infer their biological role.

Can I use this tool to map Gene Ontology terms for evolutionary classification?▼

Yes, you can map Gene Ontology terms for evolutionary classification. The tool queries InterPro to associate proteins with GO terms, enabling functional annotation and evolutionary relationship analysis across protein superfamilies.

Does the InterPro REST API integration include data from member databases like Pfam?▼

The InterPro REST API integration does include data from member databases like Pfam and PANTHER. It combines these sources to provide comprehensive protein analysis covering domain architecture mapping and functional site identification.

What are the limitations of using InterPro for domain architecture mapping?▼

InterPro domain architecture mapping relies on the REST API and requires the requests dependency. It is limited to proteins with existing entries in the database, meaning novel proteins without homologs may return incomplete or no functional annotations.