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interpro-database

Query the InterPro REST API for protein family, domain, and functional site annotations.

Updated Mar 10, 2026
Search Tags:#bioinformatics#domain#annotation#protein#interpro#gene ontology
One-click install
npx skills add https://github.com/felixboehm/biochem-allergy --skill interpro-database-felixboehm
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: interpro-database
Source: https://github.com/felixboehm/biochem-allergy/tree/main/.claude/skills/interpro-database
Command: npx skills add https://github.com/felixboehm/biochem-allergy --skill interpro-database-felixboehm

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires requests, and includes scripts (resource) and references (resource) components.

What problem does it solve?

This Skill provides comprehensive protein family, domain, and functional site annotations by querying the InterPro database, aiding in protein function prediction and classification.

Core Features & Use Cases

  • Protein Function Prediction: Determine the likely functions of uncharacterized proteins.
  • Domain Architecture Analysis: Identify and map protein domains and their order.
  • GO Term Mapping: Associate proteins with relevant Gene Ontology terms.
  • Use Case: Given a novel protein sequence, use this Skill to identify its domains, predict its function, and map it to relevant Gene Ontology terms for further research.

Quick Start

Query the InterPro database for all entries associated with the UniProt ID P04637.

Frequently Asked Questions about interpro-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I retrieve protein domain annotations and functional site data for uncharacterized proteins?▼

Protein function prediction works by querying the InterPro REST API with a sequence identifier like a UniProt ID. It integrates data from member databases such as PANTHER and SMART to identify domains and assign Gene Ontology terms.

Can I map protein sequences to Gene Ontology terms using InterPro?▼

Yes, you can map protein sequences to Gene Ontology terms using InterPro. The Skill queries the database to retrieve relevant GO terms, facilitating evolutionary classification and biological research for the target protein.

What is the best way to analyze protein domain architecture for evolutionary classification?▼

The best way to analyze protein domain architecture is querying the InterPro database to identify and map protein domains and their order. This facilitates evolutionary classification by integrating functional site annotations from member databases like Pfam and SMART.

Does the InterPro REST API support data from member databases like Pfam and PANTHER?▼

Yes, the InterPro REST API supports data from member databases like Pfam and PANTHER. It integrates multiple databases including SMART to provide comprehensive protein family, domain, and functional site annotations for biological research.

Do I need specific protein identifiers to start domain architecture analysis with InterPro?▼

You need a protein identifier such as a UniProt ID to start domain architecture analysis with InterPro. Providing this identifier allows the Skill to query the database and retrieve functional site annotations and domain mappings for your sequence.

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