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interpro-database

Aggregate protein families, domains, and GO terms from the InterPro REST API.

21|1|Updated Mar 19, 2026
Search Tags:#api#bioinformatics#annotations#domain#protein#interpro#go-terms
One-click install
npx skills add https://github.com/OwnLabAI/ownlab --skill interpro-database-ownlabai
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: interpro-database
Source: https://github.com/OwnLabAI/ownlab/tree/main/mart/skills/scientific-skills/interpro-database
Command: npx skills add https://github.com/OwnLabAI/ownlab --skill interpro-database-ownlabai

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

InterPro provides a unified view of protein families, domains, and functional sites by integrating signatures from 13 member databases. This enables researchers to rapidly infer protein function, analyze domain architectures, classify evolutionary relationships, and map GO terms without juggling multiple resources.

Core Features & Use Cases

  • REST API access for programmatic queries of protein entries, domains, families, and GO annotations.
  • Protein-centric lookups to fetch domain architectures and GO terms for UniProt IDs (e.g., P04637).
  • Batch and text-based searches to explore proteomes and annotate large datasets for downstream analyses.

Quick Start

Install a client or call the InterPro REST API to retrieve annotations for a sample UniProt ID and inspect GO terms and domain signatures.

Frequently Asked Questions about interpro-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I retrieve InterPro protein annotations for a specific UniProt ID?▼

You can retrieve InterPro protein annotations by querying the InterPro REST API with a specific UniProt ID, which returns associated families, domains, and GO terms for that entry.

Can I map GO terms to UniProt entries using the InterPro API?▼

Yes, the InterPro API provides structured parsing of GO term data, allowing you to directly map GO terms to UniProt entries.

Does the InterPro API support batch searches for annotating large proteomes?▼

Batch and text-based searches through the InterPro REST API allow you to explore proteomes and annotate large datasets for downstream analyses.

How does InterPro integrate protein domain architectures from multiple databases?▼

InterPro integrates signatures from 13 member databases to provide a unified view of protein families, domains, and functional sites.

What limitations should I expect when querying the InterPro REST API for protein families?▼

You should anticipate handling pagination properly, as robust access to InterPro REST endpoints requires structured parsing across multiple pages of returned protein family data.

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