monarch-database

Cross-species disease-gene-phenotype association querying allows you to identify candidate disease genes and model organisms across human and model species by querying the Monarch Initiative knowledge graph via Monarch API v3 endpoints.

Cross-species disease modeling identifies orthologous genes across species to study human disease mechanisms, needed when translating phenotype-to-gene mapping results from model organisms to clinical rare disease research.

Yes, you can query disease-to-disease and gene-to-phenotype associations using MONDO, OMIM, and ORPHANET identifiers through multi-ontology integration and Monarch API v3 endpoints for cross-referencing disease ontologies.

Yes, the Monarch API v3 supports HPO term resolution, ortholog mappings, and association queries to deliver structured results for cross-species disease modeling and translational research workflows.

The best way to prioritize candidate genes for rare disease research is providing a list of HPO terms to retrieve associated genes and ranked candidates from the Monarch knowledge graph using multi-ontology integration.

Limitations of cross-species phenotype-to-gene mapping include dependency on the coverage of the Monarch knowledge graph and the availability of ortholog data across species for accurate disease-gene-phenotype association results.