monarch-database

You can perform cross-species disease-gene mapping by querying the Monarch API v3 with an HPO term like HP:0001250 to retrieve associated genes and orthologs. The Skill supports robust pagination to handle large result sets during phenotype-to-gene mapping workflows.

Cross-species disease modeling uses the Monarch knowledge graph to identify functional analogs of human diseases in model organisms. You need it when researching rare diseases to find orthologs and explore disease-gene-phenotype associations beyond human data.

Yes, the Skill supports HPO term and MONDO disease lookups via the Monarch API v3 endpoints. It integrates these ontologies to retrieve disease-gene-phenotype associations and support cross-species disease modeling workflows.

Yes, the Monarch API v3 supports ortholog mapping to explore functional analogs across species for rare disease gene discovery. It retrieves disease-gene-phenotype associations and provides model organism links to identify candidate genes.

You retrieve disease-gene-phenotype associations by querying the Monarch API v3 endpoints using provided Python examples. The Skill handles robust pagination to ensure complete retrieval of association data across large cross-species datasets.

The Monarch knowledge graph relies on existing ontological annotations and cross-species data coverage, meaning phenotype-to-gene mapping is constrained by the availability of HPO and MONDO term mappings and model organism ortholog data within the API v3 endpoints.