mutation-design-aav
CommunityIterative design of high-fitness AAV mutants.
AuthorPharMolix
Version1.0.0
Installs0
System Documentation
What problem does it solve?
Propose high-fitness and high-diversity mutants of the VP1 capsid protein of Adeno-Associated Virus (AAV) through multi-round iterative optimization.
Core Features & Use Cases
- Automates multi-round design of a 28-amino-acid VP1 segment to identify variants with improved DNA packaging fitness and sequence diversity.
- Downloads and loads an in-silico oracle AAV predictor and uses ESM2 embeddings to score candidate sequences.
- Maintains population diversity using average pairwise Hamming distance and outputs a final 96-mutant library.
Quick Start
Run the mutation-design-aav skill to generate a final CSV of 96 AAV mutants with the highest predicted fitness and diversity.
Dependency Matrix
Required Modules
None requiredComponents
Standard package💻 Claude Code Installation
Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.
Please help me install this Skill: Name: mutation-design-aav Download link: https://github.com/PharMolix/OpenBioMed/archive/main.zip#mutation-design-aav Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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