pathml

Automate computational pathology workflows from WSI loading to graph analysis and ML training.

1|Updated Mar 19, 2026
One-click install
npx skills add https://github.com/JosephWoodall/noosphere --skill pathml-josephwoodall
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: pathml
Source: https://github.com/JosephWoodall/noosphere/tree/main/.agent/skills/pathml
Command: npx skills add https://github.com/JosephWoodall/noosphere --skill pathml-josephwoodall

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

PathML provides a comprehensive toolkit for computational pathology workflows, unifying loading of whole-slide images, preprocessing, graph construction, and machine learning model training into a single, modular platform.

Core Features & Use Cases

  • Loading, preprocessing, and analysis of whole-slide pathology images (WSIs) across CODEX, Vectra, and H&E modalities.
  • Graph construction and spatial analysis for cellular and tissue-level relationships, enabling downstream graph neural networks and spatial statistics.
  • End-to-end ML workflows for nucleus detection, segmentation, and marker quantification, with support for training, evaluation, and deployment pipelines.

Quick Start

Install PathML, load your slide dataset, and run the pipeline to start processing.

Frequently Asked Questions about pathml

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I build a machine learning pipeline for whole-slide image analysis?

To build a machine learning pipeline for whole-slide image analysis, you can use this toolkit to load WSIs, preprocess data, and train models. It automates end-to-end computational pathology workflows from loading to ML training.

What is the best way to run graph analysis on multiparametric pathology datasets?

The best way to run graph analysis on multiparametric pathology datasets is using a modular pipeline that constructs spatial graphs. This toolkit enables tissue-level relationship mapping and spatial statistics for downstream graph neural networks.

Can I process CODEX and Vectra modalities alongside H&E pathology images?

Yes, you can process CODEX and Vectra modalities alongside H&E pathology images. The toolkit supports loading, preprocessing, and analyzing whole-slide images across these distinct imaging modalities for scalable tissue analysis.

How does nucleus detection and segmentation work in computational pathology?

Nucleus detection and segmentation in computational pathology works by executing end-to-end ML workflows. This toolkit handles marker quantification and supports the training, evaluation, and deployment of segmentation models directly.

Do I need external dependencies to train machine learning models for tissue segmentation?

You do not need external dependencies to train machine learning models for tissue segmentation, as the toolkit operates with no required dependencies. It specifies a modular pipeline architecture with optional references and assets.

Why use a modular architecture for computational pathology workflows?

Using a modular architecture for computational pathology workflows enables scalable tissue analysis and extension via a scripts directory. This approach unifies WSI loading, graph construction, and ML training into a single platform.