pathml

Load and preprocess whole-slide images from over 160 formats.

1|Updated Mar 12, 2026
One-click install
npx skills add https://github.com/yf8578/clawomics --skill pathml-yf8578
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: pathml
Source: https://github.com/yf8578/clawomics/tree/main/skills/pathml
Command: npx skills add https://github.com/yf8578/clawomics --skill pathml-yf8578

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes scripts (resource) and references (resource) components.

What problem does it solve?

This Skill provides a comprehensive toolkit for advanced computational pathology workflows, enabling sophisticated analysis of whole-slide images and multiplexed data.

Core Features & Use Cases

  • Whole-Slide Image Analysis: Load, preprocess, and analyze WSI from over 160 formats.
  • Multiparametric Imaging: Process data from CODEX, Vectra, and MERFISH for spatial proteomics/transcriptomics.
  • Machine Learning: Train and deploy models for nucleus segmentation, classification, and graph-based spatial analysis.
  • Use Case: Analyze multiplexed immunofluorescence images to identify and quantify different immune cell populations within tumor microenvironments, and map their spatial relationships.

Quick Start

Use the pathml skill to load the whole-slide image at '/path/to/slide.svs' and generate tiles of size 256x256.

Frequently Asked Questions about pathml

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I analyze whole-slide images for computational pathology workflows?

To analyze whole-slide images for computational pathology, you can load over 160 slide formats, generate tiles, and apply preprocessing techniques like stain normalization and nucleus detection within a single workflow environment.

Can I process multiplex imaging data from CODEX, Vectra, or MERFISH?

Yes, you can process multiplex imaging data from CODEX, Vectra, and MERFISH for spatial proteomics and transcriptomics to identify immune cell populations and map their spatial relationships in tissue microenvironments.

How do I train deep learning models for nucleus segmentation and classification?

You can train and deploy deep learning models like HoVer-Net for nucleus segmentation and classification by utilizing built-in preprocessing pipelines and spatial graph construction directly on your whole-slide imaging datasets.

Does this computational pathology toolkit support single-cell analysis?

Yes, the computational pathology toolkit integrates directly with AnnData to support single-cell analysis, allowing you to transition seamlessly from whole-slide image preprocessing and nucleus detection to downstream spatial graph analysis.

What is the best way to map spatial relationships in a tumor microenvironment?

The best way to map spatial relationships in a tumor microenvironment is to process multiplexed immunofluorescence imaging data, build spatial graphs, and quantify distinct immune cell populations using integrated machine learning models.

Do I need to normalize staining before running nucleus detection on whole-slide images?

Yes, normalizing staining is a critical preprocessing step before running nucleus detection on whole-slide images, ensuring that color variations across different slides do not negatively impact the accuracy of downstream deep learning models.