regulomedb-database

To batch score SNPs for regulatory function, you provide a list of variants to the RegulomeDB v2 REST API. It returns scores from 1a to 7 based on evidence like chromatin accessibility, allowing you to identify high-priority variants for experimental validation.

A RegulomeDB score of 1a indicates strong regulatory evidence for a genetic variant, such as TF binding or eQTLs. Scores range from 1a to 7, where lower values signify higher regulatory potential to help prioritize variants for disease studies.

Yes, you can identify regulatory variants within a genomic region using region-based searches via the RegulomeDB v2 REST API. This retrieves overlapping regulatory evidence and scores for all variants located in that specified chromosomal interval.

You retrieve detailed epigenetic evidence for a single genetic variant by requesting annotation details from the RegulomeDB v2 REST API. This provides overlapping regulatory evidence including TF binding, eQTLs, and chromatin accessibility data.

Yes, this variant annotation method uses Python requests and pandas for data handling and API interaction with RegulomeDB v2. Matplotlib is also included as a dependency for visualizing the retrieved regulatory scores and evidence.