scientific-cancer-genomics

What problem does it solve?

This skill unifies COSMIC, cBioPortal, and DepMap to streamline cross-portal cancer genomics analysis, enabling researchers to correlate mutations, gene essentiality, and copy number alterations across datasets.

Core Features & Use Cases

• Unified data integration: combine mutation catalogs, molecular profiles, and dependency data from the three portals.
• Variant interpretation and signature analysis: supports mutation profiling, SBS/DBS/ID signatures, and cross-cancer comparisons.
• ToolUniverse SMCP integration: coordinates 13 ToolUniverse tools for end-to-end analysis across databases.
• Use Case: researchers study a gene across cancers to assess mutation frequency, essentiality, and CNA patterns and generate a consolidated report.

Quick Start

Perform an integrated query across COSMIC, cBioPortal, and DepMap to generate a combined mutation profile for a gene of interest.