scientific-depmap-dependencies

You can fetch gene dependency scores by querying the DepMap Portal API with a specific gene symbol. This retrieves CRISPR and RNAi gene effect metrics for cancer cell lines, which are processed into structured tabular outputs for downstream analysis.

Yes, you can retrieve drug sensitivity data alongside CRISPR and RNAi effects. This combination allows you to perform target prioritization by analyzing gene essentiality and drug response metrics across various cancer cell lines.

Yes, this tool supports integration with Cell Model Passports datasets. You can combine DepMap gene dependency and drug sensitivity data with Cell Model Passports metadata for comprehensive precision oncology research and downstream pipelines.

The tool handles DepMap API JSON responses by parsing them and processing the data into structured tabular outputs. This ensures the gene dependency scores and cell line metadata are formatted correctly for downstream analysis pipelines.

You can retrieve cell line metadata including tissue types and cancer types. This contextual information helps frame the gene dependency scores and drug sensitivity data when analyzing cancer dependencies across different cell lines.