scientific-opentargets-genetics

Retrieve target-disease scores, drug evidence, and L2G mappings from Open Targets Platform GraphQL.

3|1|Updated Feb 11, 2026

Search Tags:#bioinformatics #genetics #opentargets #target-disease #graph-ql #drug-evidence #l2g

Ready to run

npx skills add https://github.com/nahisaho/satori --skill scientific-opentargets-genetics

💬 Prompt for ChatGPT / Claude Chat▼

Please help me install this Agent Skill.
Skill: scientific-opentargets-genetics
Source: https://github.com/nahisaho/satori/tree/main/src/.github/skills/scientific-opentargets-genetics
Command: npx skills add https://github.com/nahisaho/satori --skill scientific-opentargets-genetics

SYSTEM DOCUMENTATION & REQUIREMENTS

Open Targets Platform 遺伝学スキル。Open Targets Platform GraphQL API を活用した標的-疾患アソシエーション・薬剤エビデンス・L2G 遺伝的関連・ファーマコゲノミクス検索。 ToolUniverse 連携: opentarget。

What problem does it solve?

This skill streamlines retrieval of target-disease associations, drug evidence, and L2G mappings from the Open Targets Platform, enabling researchers to prioritize targets with genetic and pharmacological context.

Core Features & Use Cases

Fetch target-disease associations using Ensembl IDs to obtain scores and disease details.
Retrieve drug evidence with mechanisms of action and clinical context for prioritized targets.
Acquire L2G variant-to-gene mappings for GWAS loci to support locus interpretation and prioritization.
Integrate results into downstream analyses and pipelines for project planning.

Quick Start

Query the Open Targets Genetics API with an Ensembl ID to fetch target-disease associations and related drug evidence.

Frequently Asked Questions about scientific-opentargets-genetics

High-intent search queries and answers about installing and using this skill.

FAQPage Schema

How do I fetch target-disease association scores using an Ensembl ID?▼

To fetch target-disease association scores, query the Open Targets Platform GraphQL API using a valid Ensembl ID. The skill retrieves structured association scores and detailed disease information to support target prioritization in research pipelines.

What is locus-to-gene mapping and when do I need it for GWAS variants?▼

Locus-to-gene (L2G) mapping identifies the most likely causal gene at a GWAS locus. You need L2G mapping when interpreting GWAS variants, prioritizing loci, and connecting genetic associations to specific target genes.

Can I retrieve drug evidence and mechanisms of action for prioritized targets?▼

Yes, you can retrieve drug evidence with mechanisms of action and clinical context for prioritized targets. The skill queries the Open Targets GraphQL API to enrich target data with pharmacological evidence.

Does this skill require any dependencies or specific environment setup?▼

No, this skill has zero dependencies and requires no specific environment setup. It directly implements Open Targets Platform GraphQL API calls and processes responses into structured data for immediate downstream analysis.

What's the best way to integrate Open Targets genetics data into downstream analysis pipelines?▼

The best way to integrate Open Targets genetics data is to use this skill to query the GraphQL API, which processes target-disease associations, drug evidence, and L2G mappings into structured data formats ready for your downstream pipelines.

Are there limitations when using GraphQL to query Open Targets Platform data?▼

Limitations include reliance on the Open Targets Platform API availability and query complexity constraints inherent to GraphQL. Ensure your Ensembl IDs and variant data are accurately formatted to avoid retrieval errors.