Store and retrieve genomic variant data in TileDB-VCF format.
npx skills add https://github.com/jasrajtulsi/GRAD-SCOPE --skill tiledbvcf-jasrajtulsi
Please help me install this Agent Skill. Skill: tiledbvcf Source: https://github.com/jasrajtulsi/GRAD-SCOPE/tree/main/.claude/skills/tiledbvcf Command: npx skills add https://github.com/jasrajtulsi/GRAD-SCOPE --skill tiledbvcf-jasrajtulsi
This Skill helps you store, query, and export large genomic variant datasets efficiently, avoiding slow merges and cumbersome file-based workflows when working with many samples or repeated region-level analyses.
Use this Skill to ingest your variant files into a TileDB-VCF dataset, query the regions you care about, and export the resulting subset for analysis.
High-intent search queries and answers about installing and using this skill.
You can query genomic variants at scale by ingesting single-sample VCF or BCF files into a TileDB-VCF dataset, allowing coordinate-aware retrieval by chromosome region and sample list for cohort analysis.
Storing VCF files in a TileDB-VCF dataset avoids slow merges by enabling incremental sample ingestion and parallel access, allowing fast regional variant queries directly on the stored array.
Yes, TileDB-VCF supports incremental dataset updates, allowing you to add new single-sample indexed VCF or BCF files to an existing population genomics dataset without reprocessing the entire cohort.
Yes, TileDB-VCF supports interoperable export workflows, allowing you to export queried variant subsets back to VCF, BCF, or tabular outputs for QC and integration with other genomics tools.
Yes, TileDB-VCF requires single-sample indexed VCF or BCF inputs to perform coordinate-aware querying and support parallel access during cohort-scale analysis.
Use TileDB-VCF when working with many samples or repeated region-level analyses in population genomics, as it replaces cumbersome file-based workflows with efficient storage and parallel access.
RamanEbrahimiManage and query genomic variant data in TileDB-VCF datasets.
ovachieverRead and write SAM/BAM/CRAM alignments and VCF/BCF variants using pysam.
yf8578Manage genomic variant data with TileDB-VCF for storage, querying, and export.
dralkhStore and query genomic variant data from indexed VCF or BCF files.
