tooluniverse-target-research

Compile citation-backed biological target profiles with evidence grading and Open Targets data.

1.6k|244|Updated Mar 3, 2025
One-click install
npx skills add https://github.com/mims-harvard/ToolUniverse --skill tooluniverse-target-research
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: tooluniverse-target-research
Source: https://github.com/mims-harvard/ToolUniverse/tree/main/skills/tooluniverse-target-research
Command: npx skills add https://github.com/mims-harvard/ToolUniverse --skill tooluniverse-target-research

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

This Skill aggregates deep target intelligence across nine parallel research paths to enable rapid, evidence-based drug target evaluation and validation.

Core Features & Use Cases

  • Multi-path target profiling: Identity, structure, interactions, pathways, expression, variants, drug interactions, and literature in a unified report.
  • Evidence grading: Assigns T1-T4 levels to claims and sources for transparent prioritization.
  • Open Targets integration: Explicit coverage of target associations and safety/druggability metrics.
  • Report-first workflow: Creates the complete target report before data collection and audits completeness.

Quick Start

Use the tool to generate a Target Intelligence Report for EGFR.

Frequently Asked Questions about tooluniverse-target-research

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I compile a comprehensive drug target profiling report across pathways, interactions, and variants?

Drug target profiling aggregates identity, structure, function, pathways, interactions, expression, variants, drug interactions, and literature into a unified, citation-backed report. It applies to targets specified by gene symbol, UniProt accession, Ensembl ID, or gene name to produce a complete Open Targets-informed assessment.

What is evidence grading in biological target research and how does it prioritize data?

Evidence grading in target research assigns T1-T4 levels to claims and sources for transparent prioritization. It enforces mandatory citations and collision-aware literature search to ensure data-minimum checks are met before completing the final assessment.

Can I use a UniProt accession or Ensembl ID for Open Targets druggability assessment?

Yes, Open Targets druggability assessment accepts UniProt accessions and Ensembl IDs alongside gene symbols or names. It explicitly covers target associations and safety or druggability metrics to generate a complete target intelligence report.

How do I perform collision-aware literature search for pathway analysis and GO annotations?

Collision-aware literature search for pathway analysis and GO annotations enforces data-minimum checks within a report-first workflow. It compiles citation-backed profiles across multiple parallel research paths to ensure accurate target evaluation.

Best way to evaluate target druggability using multi-path target intelligence?

Multi-path target intelligence evaluates druggability by aggregating deep research across nine parallel paths including structure, interactions, and variants. It creates a complete target report before data collection and audits completeness to enable rapid, evidence-based drug target validation.

What are the limitations of using automated target research for pathway analysis and variant assessment?

Automated target research for pathway analysis and variant assessment requires strict data-minimum checks and mandatory citations to mitigate limitations. It enforces a report-first workflow and evidence grading to prevent incomplete or unverified biological target profiles.