alterlab-depmap

To identify cancer gene dependencies, this Skill fetches and parses Chronos dependency scores across hundreds of cancer cell lines via the DepMap API. It processes local datasets to help you analyze gene vulnerabilities for target validation.

Yes, you can explore synthetic lethality by fetching and analyzing dependency scores across cancer cell lines using the DepMap API. The Skill guides local data processing to identify selective gene dependencies and potential synthetic-lethal partners.

Biomarker-driven drug target discovery requires Chronos datasets, DepMap API access, and local data-processing capabilities. You also integrate sample_info and mutation data to correlate identified gene dependencies with genomic biomarkers.

You correlate gene dependencies by integrating DepMap API dependency scores with sample_info and mutation data. The Skill guides local data-processing steps to parse these datasets and map genomic features to dependency scores.

Yes, this approach works for identifying selective dependencies across different cancer types by analyzing gene dependency scores across hundreds of cell lines. It applies Chronos datasets to validate targets and discover biomarker-guided vulnerabilities.