Retrieve DepMap gene dependency and drug sensitivity signals for cancer cell lines.
npx skills add https://github.com/shushuzn/Rairos --skill depmap-shushuzn
Please help me install this Agent Skill. Skill: depmap Source: https://github.com/shushuzn/Rairos/tree/main/skills/depmap Command: npx skills add https://github.com/shushuzn/Rairos --skill depmap-shushuzn
This Skill helps you identify gene dependencies and therapeutic vulnerabilities in cancer by leveraging DepMap dependency scores, drug sensitivity signals, and gene effect profiles.
Ask the Skill to query DepMap for a gene's Chronos dependency scores across cancer cell lines and return the most likely cancer-selective vulnerabilities using cell-line metadata.
High-intent search queries and answers about installing and using this skill.
To find cancer-specific gene vulnerabilities, filter CRISPR Chronos gene effect scores across annotated cancer cell lines using threshold-based interpretation to pinpoint strong dependencies in specific oncology contexts.
Yes, you can identify synthetic lethal partners by comparing CRISPR dependency patterns between biomarker-defined mutant and wild-type cell lines to surface differential vulnerabilities and validate oncology targets.
Link PRISM compound sensitivity outcomes with genomic features across cancer cell lines to prioritize predictive biomarkers for compound response and validate therapeutic vulnerabilities.
You need either the DepMap API or locally downloaded datasets like CRISPRGeneEffect and sample_info to compute correlated dependency profiles and find co-essential genes sharing pathways or complexes.
Threshold-based interpretation limits dependency strength analysis to predefined cutoffs, potentially missing subtle vulnerabilities or introducing noise from lower-quality CRISPR gene effect scores in specific cancer cell lines.
mkurmanAnalyze DepMap CRISPR Chronos scores and gene-effect data for cancer cell line dependencies.
jasrajtulsiAnalyze cancer cell line dependency profiles to identify selective gene vulnerabilities.
tassiovaleQuery the Cancer Dependency Map for gene dependency scores and drug sensitivity data.
Zeyuyang-0420Query gene dependency scores and drug sensitivity data across cancer cell lines.
