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AlterLab-IEU
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alterlab-interpro

Fetch comprehensive InterPro annotations for a given protein identifier via REST API.

58|9|Updated Mar 16, 2026
Search Tags:#bioinformatics#domain#annotation#protein#interpro#go-terms
One-click install
npx skills add https://github.com/AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-interpro
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: alterlab-interpro
Source: https://github.com/AlterLab-IEU/AlterLab-Academic-Skills/tree/main/skills/databases/alterlab-interpro
Command: npx skills add https://github.com/AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-interpro

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

Researchers need reliable, consolidated protein function annotations from InterPro across multiple member databases to interpret sequences quickly.

Core Features & Use Cases

  • InterPro REST API access to retrieve protein entries, domain architectures, GO terms, and cross-references.
  • Programmatic queries: look up proteins, fetch specific InterPro entries, and batch annotate sequences.
  • Use Case: annotate a UniProt protein to obtain its domain list, GO terms, and implicated families for downstream analysis.

Quick Start

Analyze a UniProt ID like P04637 to fetch its InterPro annotations and GO terms.

Frequently Asked Questions about alterlab-interpro

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I fetch InterPro annotations for a UniProt protein identifier?▼

To fetch InterPro annotations, submit a valid UniProt ID like P04637 to retrieve comprehensive domain architectures, GO terms, and cross-references via the InterPro REST API endpoints.

Can I batch annotate protein sequences with InterPro domain and GO term mappings?▼

Batch annotate protein sequences by querying multiple UniProt entries programmatically to obtain their consolidated domain list, GO terms, and implicated protein families for downstream analysis.

What is InterPro annotation used for in protein function prediction?▼

InterPro annotation integrates protein domain architectures and GO term mappings across member databases to quickly interpret sequences and predict protein functions reliably.

Does this InterPro annotation approach work with UniProt entries for domain architecture analysis?▼

Yes, it queries InterPro REST API endpoints using UniProt entries to retrieve specific domain architectures, cross-references, and implicated families for detailed domain architecture analysis.

How do I map GO terms to a protein using InterPro entries?▼

Map GO terms by querying InterPro entries for a given protein identifier, which retrieves associated GO terms and cross-references directly from the InterPro REST API.

What are the limitations of using InterPro REST API for protein annotation?▼

InterPro REST API queries require valid protein identifiers like UniProt IDs to retrieve annotations, meaning sequences without existing UniProt entries cannot be annotated directly through this method.

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