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Hung-3008
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interpro-database

Consolidate protein function and domain annotations via the InterPro REST API.

1|Updated Mar 4, 2026
Search Tags:#bioinformatics#rest-api#uniprot#protein-annotation#domain-architecture#interpro#go-terms
One-click install
npx skills add https://github.com/Hung-3008/agusta --skill interpro-database-hung-3008
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: interpro-database
Source: https://github.com/Hung-3008/agusta/tree/main/.agents/skills/interpro-database
Command: npx skills add https://github.com/Hung-3008/agusta --skill interpro-database-hung-3008

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

InterPro provides a centralized interface to access protein family, domain, and functional site annotations by integrating 13 member databases, empowering researchers to quickly predict protein function and analyze domain architecture without juggling multiple resources.

Core Features & Use Cases

  • Unified access: REST API endpoints to fetch protein entries, domain annotations, GO terms, and cross-references to UniProt, Pfam, and PDB.
  • Protein characterization: Determine domain architecture, family classification, and evolutionary relationships for model proteins and proteomes.
  • GO term mapping: Retrieve GO annotations associated with InterPro entries for functional inference.
  • Batch and search workflows: Scan multiple proteins, perform text or taxonomy searches, and inspect domain-level details for comparative analyses.

Quick Start

Query InterPro for the UniProt entry P04637 to retrieve its domains and GO terms.

Frequently Asked Questions about interpro-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I retrieve protein domain annotations and GO terms for a specific UniProt entry?▼

To retrieve protein domain annotations and GO terms, query the InterPro REST API with a UniProt identifier like P04637. This consolidates domain architectures, family classifications, and cross-referenced functional annotations across UniProt, Pfam, and PDB into unified results.

What is the best way to map InterPro entries to GO terms for functional inference?▼

Mapping InterPro entries to GO terms is done by querying the InterPro REST API, which retrieves associated Gene Ontology annotations for functional inference. This provides centralized access to integrated functional site data across 13 member databases.

Can I perform batch protein searches to analyze domain architecture across multiple proteomes?▼

Batch protein searches are supported through the InterPro REST API, allowing you to scan multiple proteins and perform taxonomy searches. You can inspect domain-level details and determine evolutionary relationships for comparative genomics workflows.

Does the InterPro database API cross-reference entries from both Pfam and PDB?▼

The InterPro database API cross-references entries from both Pfam and PDB, alongside UniProt. It integrates 13 member databases to deliver domain architectures and functional site annotations for protein characterization workflows.

How do I analyze protein family classification and evolutionary relationships using InterPro?▼

Analyzing protein family classification and evolutionary relationships involves querying the InterPro REST API to fetch family classifications and domain architectures. This enables comparative genomics and evolutionary analysis for model proteins and proteomes.

What are the limitations of using the InterPro REST API for domain architecture analysis?▼

Limitations of using the InterPro REST API for domain architecture analysis include dependency on remote endpoint availability and relying on pre-computed annotations from 13 member databases rather than performing novel sequence alignments dynamically.

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