brenda-database

Query BRENDA enzyme kinetic parameters via its SOAP API.

Updated Mar 10, 2026
One-click install
npx skills add https://github.com/Yezez9/Research-Agent --skill brenda-database-yezez9
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: brenda-database
Source: https://github.com/Yezez9/Research-Agent/tree/main/scientific-skills/brenda-database
Command: npx skills add https://github.com/Yezez9/Research-Agent --skill brenda-database-yezez9

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires zeep, requests, pandas, matplotlib, seaborn, numpy, and includes scripts (resource) and references (resource) components.

What problem does it solve?

This Skill provides programmatic access to the BRENDA enzyme database, enabling researchers to retrieve detailed enzyme kinetic parameters, reaction information, and organism-specific data, thereby accelerating biochemical research and enzyme discovery.

Core Features & Use Cases

  • Kinetic Parameter Retrieval: Access Km, kcat, and Vmax values for enzymes across various organisms and substrates.
  • Reaction Information: Retrieve detailed reaction equations, stoichiometry, and cofactor requirements.
  • Enzyme Discovery: Search for enzymes based on substrates, products, or reaction patterns.
  • Use Case: A metabolic engineer needs to find enzymes that can efficiently convert a specific substrate into a desired product under high-temperature conditions. This Skill can query BRENDA for suitable enzymes, compare their kinetic properties, and identify thermophilic variants.

Quick Start

Use the brenda-database skill to get Km values for enzyme 1.1.1.1.

Frequently Asked Questions about brenda-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I retrieve enzyme kinetic parameters like Km and kcat from the BRENDA database?

To retrieve enzyme kinetic parameters from the BRENDA database, you can programmatically query its SOAP API to access comprehensive Km, kcat, and Vmax values across various organisms and substrates.

Can I search for specific enzymes based on substrate specificity and reaction equations?

Yes, you can search for enzymes based on substrate specificity and reaction equations by querying the BRENDA database to retrieve detailed reaction information, stoichiometry, and cofactor requirements.

What Python libraries do I need to query BRENDA enzyme data?

You need the zeep, requests, pandas, matplotlib, seaborn, and numpy Python libraries to query BRENDA enzyme data, handle SOAP API communication, and perform data retrieval and analysis.

Do I need authentication credentials to access the BRENDA SOAP API?

Yes, accessing the BRENDA SOAP API requires valid authentication credentials to successfully retrieve enzyme kinetic parameters, reaction equations, substrate specificities, and organism data.

Is there a way to find thermophilic enzyme variants for metabolic engineering workflows?

You can find thermophilic enzyme variants for metabolic engineering workflows by querying the BRENDA database to compare kinetic properties and identify suitable enzymes for high-temperature conditions.

What are the limitations of using zeep for BRENDA database data retrieval?

Using zeep for BRENDA database data retrieval is limited by its dependency on specific Python libraries like pandas and numpy for analysis, and requires valid authentication credentials for successful SOAP API queries.