clinpgx-database

Query the ClinPGx REST API for gene-drug interactions and CPIC guidelines.

557|98|Updated Nov 7, 2025

Search Tags:#drug response #pharmacogenomics #clinpgx #gene-drug interaction #cpic guidelines #precision medicine

Ready to run

npx skills add https://github.com/jimmc414/Kosmos --skill clinpgx-database-jimmc414

💬 Prompt for ChatGPT / Claude Chat▼

Please help me install this Agent Skill.
Skill: clinpgx-database
Source: https://github.com/jimmc414/Kosmos/tree/main/kosmos-claude-scientific-skills/scientific-skills/clinpgx-database
Command: npx skills add https://github.com/jimmc414/Kosmos --skill clinpgx-database-jimmc414

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires requests, and includes scripts (resource) and references (resource) components.

What problem does it solve?

This Skill provides access to comprehensive pharmacogenomics data, enabling precise understanding of how genetic variations influence drug response and guiding personalized treatment decisions.

Core Features & Use Cases

Gene-Drug Interaction Queries: Retrieve detailed information on how specific genes affect drug metabolism, efficacy, and toxicity.
CPIC Guideline Access: Obtain evidence-based clinical practice guidelines for genotype-guided drug prescribing.
Allele and Variant Information: Look up functional status, population frequencies, and clinical significance of genetic variants.
Use Case: A clinician needs to prescribe clopidogrel to a patient. They use this Skill to check the patient's CYP2C19 genotype and retrieve CPIC guidelines, determining if an alternative medication is needed due to poor metabolizer status.

Quick Start

Use the clinpgx-database skill to find gene-drug interactions for CYP2C19 and clopidogrel.

Frequently Asked Questions about clinpgx-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema

How do I retrieve CPIC guidelines for gene-drug interactions using an API?▼

You can retrieve CPIC guidelines for gene-drug interactions by querying the ClinPGx REST API, which provides structured data on clinical practice guidelines, allele functions, and drug label information for precision medicine applications.

How do I check pharmacogenomics data for clopidogrel and CYP2C19?▼

To check pharmacogenomics data for clopidogrel and CYP2C19, you can query the ClinPGx REST API to retrieve specific gene-drug interaction details, clinical guidelines, and allele functional status to support clinical decision making.

Can I use Python requests to access pharmacogenomic variant information?▼

Yes, you can use the Python requests library to access pharmacogenomic variant information by making programmatic calls to the ClinPGx REST API to look up functional status, population frequencies, and clinical significance.

What is the best way to integrate precision medicine data into clinical decision support systems?▼

The best way to integrate precision medicine data into clinical decision support is by using the ClinPGx REST API to programmatically fetch gene-drug interactions, CPIC guidelines, and allele functions for drug safety assessments.

Does this pharmacogenomics database API provide drug metabolism and toxicity information?▼

Yes, the pharmacogenomics database API provides detailed information on how specific genes affect drug metabolism, efficacy, and toxicity, along with population frequencies and clinical significance of genetic variants.

What limitations should I consider when querying gene-drug interactions for research analysis?▼

When querying gene-drug interactions for research analysis, consider that data access depends on the ClinPGx REST API availability and the Python requests library, requiring structured handling of allele functions and CPIC guideline responses.