Query GTEx API v2 for tissue-specific gene expression, eQTLs, and sQTLs.
npx skills add https://github.com/Hung-3008/agusta --skill gtex-database-hung-3008
Please help me install this Agent Skill. Skill: gtex-database Source: https://github.com/Hung-3008/agusta/tree/main/.agents/skills/gtex-database Command: npx skills add https://github.com/Hung-3008/agusta --skill gtex-database-hung-3008
Facilitates access to GTEx data to interpret how genetic variation influences gene expression across tissues, aiding the assignment of regulatory mechanisms to GWAS signals.
Identify a gene of interest and query its tissue-specific expression and eQTLs across GTEx tissues.
High-intent search queries and answers about installing and using this skill.
To retrieve tissue-specific gene expression from GTEx, query the API v2 endpoints using a GENCODE ID to get median expression levels across 54 tissues in v8 or v10 datasets.
Find eQTLs and sQTLs for a specific variant by querying GTEx API v2 endpoints, which return association data including p-values and q-values to link variants with regulatory effects across tissues.
Connect GWAS signals to regulatory mechanisms by querying GTEx eQTL and sQTL data to identify tissues where your variants affect gene expression, validating regulatory hypotheses with tissue-specific data.
Querying GTEx data requires a target gene or variant, corresponding GENCODE IDs, and proper handling of API v2 pagination to successfully retrieve expression and QTL associations.
Use GTEx v10 over v8 to access updated tissue-specific gene expression and QTL annotations, allowing comparative analysis across different dataset versions to validate regulatory findings.
monarch-initiativeIdentify enriched pathways, GO terms, and disease associations from gene lists.
JosephWoodallQuery the GTEx API for tissue-specific gene expression and eQTL/sQTL associations.
rubenslivQuery GWAS Catalog REST APIs for SNP-trait associations and study metadata.
LeonChaoXRetrieve tissue-specific gene expression, eQTLs, and sQTLs from the GTEx Portal API.
