gtex-database

Name: gtex-database
Availability: InStock
Author: OwnLab

Query GTEx REST API v2 endpoints for tissue-specific gene expression, eQTLs, and sQTLs.

21|1|Updated Mar 19, 2026

Search Tags:#expression #genetics #gwas #eqtl #gtex #sqtl #tissues

Ready to run

npx skills add https://github.com/OwnLabAI/ownlab --skill gtex-database-ownlabai

💬 Prompt for ChatGPT / Claude Chat▼

Please help me install this Agent Skill.
Skill: gtex-database
Source: https://github.com/OwnLabAI/ownlab/tree/main/mart/skills/scientific-skills/gtex-database
Command: npx skills add https://github.com/OwnLabAI/ownlab --skill gtex-database-ownlabai

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

Access to GTEx data for tissue-specific gene expression and genetic regulation is essential for interpreting GWAS loci and understanding tissue context. This skill enables programmatic querying of GTEx v10/v8 endpoints for median expression, eQTLs, and sQTLs, streamlining integration into analyses and reports.

Core Features & Use Cases

GTEx REST API v2 endpoints for expression, eQTL, sQTL, and tissue metadata across 54 tissues.
Multi-tissue expression profiling, eQTL and sQTL discovery, and tissue specificity analyses to aid GWAS interpretation.
Workflows and best practices for dataset versioning, large-scale downloads, and programmatic data retrieval.

Quick Start

Run a GTEx query to fetch median expression and significant eQTL data for a gene of interest.

Frequently Asked Questions about gtex-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema

How do I query GTEx tissue expression and eQTL data for a specific gene?▼

To query GTEx tissue expression and eQTLs, use the GTEx REST API v2 endpoints with either the geneSymbol or gencodeId parameter to retrieve structured JSON containing median expression and significant regulatory variants.

Can I retrieve sQTL data across multiple tissues using the GTEx API?▼

Yes, you can retrieve sQTL data across 54 tissues by querying the GTEx REST API v2 endpoints. The workflow returns structured JSON for splicing regulation analysis while handling dataset versioning and pagination automatically.

What is the difference between querying gtex_v10 and gtex_v8 datasets?▼

Querying gtex_v10 and gtex_v8 datasets targets different GTEx data releases, specified via the datasetId parameter. Selecting the appropriate dataset version ensures you retrieve the correct tissue-specific expression and QTL data for your analysis.

How does tissue-specific gene expression help interpret GWAS loci?▼

Tissue-specific gene expression helps interpret GWAS loci by identifying which tissues are most affected by genetic variants, while eQTL and sQTL data reveal regulatory mechanisms underlying GWAS signals across the 54 GTEx tissues.

Does the GTEx API support large-scale data retrieval for multiple genes?▼

Yes, the GTEx API supports large-scale data retrieval for multiple genes by utilizing built-in pagination handling within the workflow, allowing systematic programmatic querying of expression and QTL datasets.

What are the limitations when using GTEx API v2 for eQTL analysis?▼

Limitations of GTEx API v2 for eQTL analysis include handling pagination constraints for large-scale downloads and strictly managing dataset version compatibility between gtex_v10 and gtex_v8 to ensure accurate data retrieval.