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gtex-database

Fetch tissue-specific gene expression and regulatory QTL data from GTEx.

94|11|Updated Mar 26, 2026
Search Tags:#api#bioinformatics#gene-expression#eqtl#gtex#tissue-expression#qtl-analysis
One-click install
npx skills add https://github.com/swaruplab/operon --skill gtex-database-swaruplab
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: gtex-database
Source: https://github.com/swaruplab/operon/tree/main/src-tauri/protocols/gtex-database
Command: npx skills add https://github.com/swaruplab/operon --skill gtex-database-swaruplab

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

GTEx provides a centralized resource for tissue-specific gene expression and genetic regulation; this Skill enables programmatic access to GTEx data for cross-tissue interpretation.

Core Features & Use Cases

  • Expression profiling: Retrieve median TPM across tissues for a given gene.
  • eQTL and sQTL lookup: Query significant eQTLs and sQTLs across tissues for a gene or variant.
  • Multi-tissue analysis: Compare expression and regulation between tissues to support GWAS interpretation and functional genomics studies.

Quick Start

Query GTEx for a gene's tissue-specific expression and cis-eQTL data across tissues.

Frequently Asked Questions about gtex-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I query GTEx tissue-specific gene expression for a specific gene?▼

To query GTEx tissue expression, use the medianGeneExpression endpoint to retrieve median TPM values across tissues for a given gene. The Skill handles pagination and returns structured results for downstream analytics.

What is the difference between eQTL and sQTL data in GTEx?▼

eQTLs (expression quantitative trait loci) identify variants affecting gene expression levels, while sQTLs affect splicing patterns. Use the singleTissueEqtl and singleTissueSqtl endpoints to query significant associations across tissues.

Can I use GTEx v10 data for eQTL analysis or is v8 required?▼

Both gtex_v10 and gtex_v8 datasets are supported for eQTL analysis. This Skill implements dataset selection, allowing you to query significant eQTLs and sQTLs from either version for cross-tissue interpretation.

How do I retrieve cis-eQTL data across multiple tissues for GWAS interpretation?▼

Query the singleTissueEqtl endpoint with your gene or variant of interest to retrieve significant cis-eQTLs across tissues. The Skill returns structured results supporting multi-tissue analysis for GWAS interpretation.

Does this approach work for identifying eGenes across different tissues?▼

Yes, use the egene endpoint to identify genes with at least one significant eQTL in a given tissue. This enables cross-tissue comparison of genetic regulation to support functional genomics studies.

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