interpro-database

Query the InterPro database for protein family, domain, and functional site annotations.

Updated Mar 10, 2026
One-click install
npx skills add https://github.com/Yezez9/Research-Agent --skill interpro-database-yezez9
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: interpro-database
Source: https://github.com/Yezez9/Research-Agent/tree/main/scientific-skills/interpro-database
Command: npx skills add https://github.com/Yezez9/Research-Agent --skill interpro-database-yezez9

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes scripts (resource) and references (resource) components.

What problem does it solve?

This Skill helps researchers understand protein function, structure, and evolutionary relationships by querying the comprehensive InterPro database.

Core Features & Use Cases

  • Protein Function Prediction: Identify potential functions of unknown proteins.
  • Domain Architecture Analysis: Determine the structural and functional domains within a protein sequence.
  • Protein Family Classification: Assign proteins to known families and superfamilies.
  • GO Term Mapping: Retrieve Gene Ontology terms associated with protein annotations.
  • Use Case: Given a UniProt ID for a newly discovered protein, use this Skill to find its known domains, predict its function, and map it to relevant Gene Ontology terms.

Quick Start

Use the interpro-database skill to get all InterPro entries for the UniProt ID P04637.

Frequently Asked Questions about interpro-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I find protein domains and functional sites for a UniProt ID?

To find protein domains and functional sites for a UniProt ID, you can query the InterPro database. This integrates annotation data from multiple member databases like Pfam and SMART to provide comprehensive domain architecture and functional site mapping.

Can I retrieve Gene Ontology terms associated with specific protein annotations?

Yes, you can retrieve Gene Ontology terms associated with specific protein annotations. By querying the InterPro database with a protein identifier, the system maps the retrieved entries to relevant GO terms for functional prediction.

What is the best way to predict the function of an unknown protein sequence?

The best way to predict the function of an unknown protein sequence is by performing protein family classification. Querying InterPro with a protein identifier helps assign it to known families and superfamilies, facilitating accurate function prediction.

Does InterPro database annotation integrate data from Pfam and SMART?

Yes, InterPro database annotation integrates data from Pfam and SMART. It consolidates protein family, domain, and functional site information from multiple member databases to provide unified protein function and structural insights.

How can I programmatically access InterPro entries for domain architecture analysis?

You can programmatically access InterPro entries for domain architecture analysis using REST API interactions. This allows automated retrieval of protein and entry details to determine structural and functional domains within a protein sequence.