monarch-database

Yes, you can retrieve cross-species disease models by querying Monarch API v3 with MONDO or OMIM identifiers. The API returns orthologs and associated genes, enabling comparative studies of human diseases in model organisms.

Yes, you can retrieve cross-species disease models by querying Monarch API v3 with MONDO or OMIM identifiers. The API returns orthologs and associated genes, enabling comparative studies of human diseases in model organisms.

Yes, operational use requires internet access to reach the Monarch API v3. All disease-gene associations, phenotype-to-gene mappings, and HPO term lookups are fetched live from the external Monarch Initiative knowledge base.

Phenotype-to-gene lookups require inputs expressed as MONDO, OMIM, or HPO identifiers. These standardized ontology identifiers allow the Monarch API v3 to accurately retrieve matching gene associations across humans and model organisms.

Querying the Monarch Initiative API v3 with a set of HPO terms is the best way to fetch associated candidate genes for rare disease gene discovery. This cross-species knowledge base links phenotypes directly to human and model organism genes.

Cross-species disease-gene mapping via Monarch retrieves orthologs and model organism phenotypes that human-only databases lack. This broader context aids phenotype-driven gene discovery and reveals evolutionary conservation relevant to rare diseases.